Comparison of α-adrenoceptor involvement in the antinociceptive action of tizanidine and clonidine in the mouse
T Kameyama, T Nabeshima, K Matsuno… - European journal of …, 1986 - Elsevier
The effect of drugs that influence the opioidergic and monoaminergic neuronal systems on
the antinociceptive action of tizanidine [5-chloro-4-(2-imidazolin-2-yl-amino)-2, 1, 3-
benzothiodiazole] was compared with their effect on the action of clonidine. The potency of
the clonidine-induced antinoceptive action was 1.83 and 7.75 times greater than that of
tizanidine in the tail-flick and acetic acid-induced writhing tests, respectively. The action of
tizanidine and clonidine was completely antagonized by pretreatment with yohimbine, an α …
the antinociceptive action of tizanidine [5-chloro-4-(2-imidazolin-2-yl-amino)-2, 1, 3-
benzothiodiazole] was compared with their effect on the action of clonidine. The potency of
the clonidine-induced antinoceptive action was 1.83 and 7.75 times greater than that of
tizanidine in the tail-flick and acetic acid-induced writhing tests, respectively. The action of
tizanidine and clonidine was completely antagonized by pretreatment with yohimbine, an α …
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